It is possible to run some Windows applications using wine, you can look up compatibility here: https://appdb.winehq.org/ though you would likely have issues. There may be alternatives that you can use for example instead of Office 2016 you could use LibreOffice, OpenOffice, SoftMaker Office, or WPS Office.
In terms of antivirus there is no antivirus by ...
latest version thats in tied to ubunthu repo can be found here:
that is a debian packaged version
other wise if you want the latest version you can download source files and build it
there are instruction in the "README.cmake" file