I use the English Dvorak keyboard layout and I'm not able to use CTRL + X, C, or V to manipulate files in io.elementary.files files.
Hitting the QWERTY equivalents (Q/J/K) does nothing; except Q where X is, which closes the program like Q should. Shortcuts such as CTRL + A to select all files works. CTRL + L focuses the path bar. I can copy and paste using the Right Click menu. It is only this application which seems to have this problem.
I have completed Language Support setup. I have only English (Dvorak) listed in the Keyboard settings and the install was done in Dvorak as well. I'm using a Lenovo Y510p with kernel 4.15.0-39-lowlatency and the problem happens regardless of NVIDIA or Intel setup. I am fully updated as of 2018 Nov 18th 15:16.
Side note: I think I had this problem in release-loki as well, but I wasn't really using elementary OS at the time, so I just moved on.